These drugs deplete the active form of the vitamin by inhibiting the enzyme vitamin K epoxide reductase and thus the recycling of the inactive vitamin K epoxide back to the active reduced form of vitamin K. They are used as anticoagulant medications in the prevention of thrombosis, and in pest control, as rodenticides. Vitamin K antagonists (VKAs) have been the mainstay of anticoagulation therapy for more than 50 years. The term "vitamin K antagonist" is technically a misnomer, as the drugs do not directly antagonize the action of vitamin K in the pharmacological sense, but rather the recycling of vitamin K. Vitamin K antagonists ( VKA) are a group of substances that reduce blood clotting by reducing the action of vitamin K.
In menaquinone the side chain is composed of a varying number of isoprenoid residues.
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